Abstract - 2018 Volume.9 Issue.5

There are two types of diabetes: Diabetes Mellitus and Diabetes insipidus. Diabetes mellitus occurs because of pancreatic beta-cell destruction and insulin de?ciency, Diabetes insipidus occurs because of the deficiency of vasopressin (AVP). This study was conducted to determine the In-silico efficacy and suitability of the chemical constituents of medicinal plants that are used to cure diabetes. The chemical compounds of medicinal plants: Bauhinia Variegata, Prunella Vulgaris, Aloe Vera, and Clematis Montana, used to cure diabetes were checked for toxicity, only 5 chemical constituents lying in non-toxic classes, were further analyzed and docked with mutated Insulin-B and Vasopressin proteins. All the chemical compounds best fit in the pockets of proteins and does not leave the complex, in all the docked complexes the common interacting amino acid residues were ALA, VAL, LEU, HIS, LYS, TRP, and SER.  It determines their suitability to be used as medicine against diabetes.

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