Abstract - 2017 Volume.8 Issue.2

Solifenacin succinate is a competitive muscarinic acetylcholine receptor antagonist. This article describes development and validation for the determination of related substances of Solifenacin succinate in Solifenacin succinate Tablets by using a high performance liquid chromatography. The high performance liquid chromatography resolution was achieved on a Waters Xterra RP-8 250 x 4.6, 5µ, column with a gradient elution at a flow rate of 1.2 mL/min. The detection was performed by a photo diode array Detector. The method was validated in the concentration range of Limit of quantitation to 150% of working concentration. The intra and inter-day precision and accuracy were within Limit. The overall mean recoveries of Solifenacin succinate impurities were in the range of 90.0% to 110.0% for Limit of Quantitation, 50%, 100% and 150%.

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