Abstract - 2014 Volume.5 Issue.3

Oral route has been the most convenient mode for the drug delivery. It has been received more attention in the pharmaceutical field because of more flexibility in developing of dosage form than any other route of drug delivery. The present research work was aimed to enhance the performance of existing water insoluble drug molecule with suitable technique. Particle size of water insoluble molecule (Celecoxib) was reduced to nanometer range using Dyno Mill. The suspension was dried to powder blend using fluidized bed granulator and spray drier. The tablets were manufactured by wet granulation and direct compression technique. The blend and tablets were characterized for particle size, micromeritic data, quality control parameters and in vitro drug release. The applied technique was successful in enhancing the dissolution behavior of celecoxib.

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